This study is the first in the development of SCF Pharma's line of omega-3-based cosmetic products. Thirty-three (33) volunteers will be enrolled in the study. Its aim is to verify the hydrating potential of a serum as well as three different cream formulations. The study also seeks to verify whether these products can cause irritation. This study extends over a total period of two weeks. 

Fatty acids are the basic building blocks of fats found in all living organisms. The essential fatty acids are divided into two main subcategories: omega-3 and omega-6. These oils are naturally present almost everywhere in consumer products. They oppose each other in their mechanism of action at the molecular level. It is widely recognized in the scientific literature that omega-3s have anti-inflammatory properties as opposed to omega-6s which have mechanisms of action that promote inflammation. In food, it is relatively easy to make choices in favor of omega 3. In skin care, however, it is much more difficult to find products with an omega-3 fatty compound. Considering that skin can be sensitive to many irritating factors, it's natural to wish that the base ingredients of a moisturizer has naturally anti-inflammatory properties rather than the other way around. SCF Pharma, which specializes in pre-activated omega-3 oils (monoglycerides or MAG), is currently developing a line of moisturizing products to address this need.

Omega-3 monoglycerides (MAG-O3) developed by SCF Pharma are a new generation of omega-3s that are believed to be more effective due to their better absorption by the body. Omega-3s are generally ingested as dietary supplements in the form of ethyl esters which require several steps of metabolization before they can be absorbed by the tissues. Monoglycerides are the final form of these metabolization steps. The MAG-03s act at the cellular level to activate the production of SPM (specialized pro-resolution mediators) which are key players against inflammation. The potential applications of MAG-03s in resolving inflammation are multiple, both in the form of supplements, for protection against several diseases linked to internal inflammation, and at the topical level. The skin is an organ that undergoes various attacks producing inflammation. To treat topical inflammation, a cream base consisting of water and a fatty substance is generally combined with an active medication. Hence, MAG-03s could play the roles of fatty substance and active ingredient simultaneously.

This study seeks to verify the moisturizing potential as well as the risks associated with the topical MAG-03 product from SCF Pharma. Applicants must be between 18 and 65 years old and have dry skin. They must not have an active skin disease requiring drug treatment. During the first visit, the study is explained to the candidate. If the candidate meets the eligibility criteria and is still interested in participating, the candidate may be enrolled in the study.